Endocrine Abstracts

Introduction: Homocysteine is an intermediate sulfur amino acid in the metabolic pathways of cysteine production from methionine, which is increasingly involved in various pathological processes (arterial thrombosis, depression, schizophrenia, dementia). We are interested in the course of our work to study its implication on the lipid balance in patients with venous thrombosis.Materials and methods: This is an observational case-control study, comparing ...

Introduction: The aim of this study was to investigate the characteristics of glucocorticoid-induced diabetes (GCID) in 18 non-diabetic patients before the initiation of corticosteroid therapy.Patients and Methods: It is a retrospective study including non-diabetic hospitalized patients who developed diabetes after initiation of corticosteroid therapy.Results: Eighteen patients (5 males/13 females) with a mean age of 59.5 years wer...

Introduction: Thyroid pathology is common in women of reproductive age. Evaluation of thyroid function is classically recommended in cases of recurrent abortion. The presence of dysthyroidism or antithyroid antibodies increases the risk of abortion. We report two observations of hypofertility related to thyroid pathology and discuss the therapeutic course.Case 1: A 33 year old woman was referred for etiological investigation of recurrent abortion. She pr...

Introduction: Cardiovascular complications are well known in type 2 diabetes with other factors of cardiovascular disease. Recently, with the intensive treatment of type 1 diabetes, many studies have focused on macrovascular complications in type 1 diabetes. The aim of our study was to determine the long-term cardiovascular risk factors and macrovascular complications in type 1 diabetic patients.Patients and methods: A retrospective study involving 45 pa...

IntroductionType 3 autoimmune polyendocrine syndrome (APS-3) is defined by the presence of an autoimmune thyroid disease and another autoimmune illness, excluding Addison’s disease; this is a frequent combination. Graves’ disease (GD) is an autoimmune disorder affecting approximately 0.5% of general population. It’s occurrence in autoimmune polyendocrine syndrome (APS) is less common than Hashimoto thyroiditis. The aim of our study was to ...

IntroductionAutoimmune Polyendocrine Syndrome (APS) is defined by the presence of 2 or more autoimmune induced endocrine failures in a single patient. There are 4 types of APS: type1 including chronic muco-cutaneous candidiasis, hypoparathyroidism, Addison disease (AD) and ectodermal dystrophy, APS type 2 and 3 containing autoimmune thyroide disease (AITD), type1 diabetes (DT1) with (type2) or without adrenal failure (type3) and type 4 not falling into t...

IntroductionVasculitis with antineutrophilic cytoplasmic antibodies (ANCA) has been reported in patients treated with anti-thyroid drugs, especially Propylthiouracil and exceptionally with benzylthiouracil (BTU). We present here a case of ANCA-anti-MPO-associated vasculitis related to BTU.Case presentationA 46 old women was treated with BTU during 18 months for Basedow’s...

Introduction: Wegener’s granulomatosis is a necrotizing vasculitis that can affect the central nervous system. Pituitary involvement is exceptional, but may be underestimated. Pituitary involvement in Wegener’s disease is rare, and is mainly expressed as diabetes insipidus.Clinical case: A 33-year-old man was admitted to hospital in 2009 with bilateral optic neuropathy, altered general condition revealing Wegener’s disease with rhinosinus ...

Introduction: The causes of gonadotropic insufficiency are many and varied. Pituitary lymphomas are a rare and difficult-to-diagnose cause.Case report: We report the case of a 30-year-old female patient who was admitted to the internal medicine department for an altered general condition with febrile headache. She reported secondary amenorrhea evolving for three months. The pregnancy test was negative. On physical examination, the patient was cachectic a...

Introduction: Diabetic neuropathy is the most common cause of neuropathy worldwide and is known to affect approximately half of all diabetic patients. It significantly impairs the quality of life of patients.Aim of the study: To establish the predictive factors of distal symmetric polyneuropathy (DSPN) in diabetic patients.Methods: This is a descriptive cross-sectional study including 116 patients. The diagnosis of PNDS was establi...